MTHFR affects about 18% of the population


What is MTHFR? MTHFR is a gene that provides the body with particular instructions to make a certain enzyme called MethyleneTetraHydrofolate Reductase MTHFR.  

Why is it important? When we eat foods that contain folic acid, MTHFR converts the folic acid into methyl-folate which is folates active form required for methylation.

What does methyl-folate do? Methyl-folate is essential for methylation. Methylation helps the body in numerous processes including digestion, metabolism of hormones, production of DNA and detoxification.

There are two main genetic alterations that you could have, C677T and A1298C. Because you have two copies of every gene, there are a few different possible combination of these genes you could have. The general idea is that you take on one copy from your mother and one copy from your father. If mum and dad have no copies of the gene mutation, then you would not have any either. If they have two copies of one of the genetic mutations, then you would end up with one copy from each of them, etc. The only way to find out is to be tested.

Health conditions and symptoms associated with an MTHFR gene alterations:





Chronic Fatigue



Erectile Dysfunction


High Blood Pressure

Malabsorption (increased daily pooping)

Mental Fog

Neuropathy, Numbness, etc

Let’s look at digestion and methylation a little closer.  The MTHFR gene is required for optimal methylation of nutrients (breakdown of food) for absorption of vitamins, minerals, macronutrients, micronutrients and removal of waste products.

Foods to eat: Natural wholefoods containing folate.





Dark leafy green vegetables – kale, spinach, bok choy daily

Grass fed meats, butter, ghee


Organic eggs

Peanuts, raw


Sunflower seeds

Supplements that state: methyl-folate, methyl-B12 (these are able to be metabolised fully)

Foods/Products to avoid: processed foods that contain synthetic folic acid.

Aluminium containing deodorants

Chemical cleaning products

Supplements containing synthetic folic acid including the Pill and proton pump inhibitors.

When the genetic mutation of MTHFR is present, this may affect hormonal and neuronal transmitters, brain function, ADHD, depression, schizophrenia, cardiovascular diseases, cholesterol, migraines, autoimmune diseases and more.  When testing for the MTHFR gene, your histamine levels will be automatically tested as there is a risk of thrombosis associated with high histamine levels depending on your gene combination.

If a relative or you suspect that you may have the MTHFR gene mutation we can order the blood sample test for you.

Janelle Tanzer 

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